A convergent and enantioselective synthesis of (+)-amurensinine via selective C-H and C-C bond insertion reactions.
نویسندگان
چکیده
A convergent and enantioselective synthesis of the natural product amurensinine is described. The synthetic strategy takes advantage of mild and selective C-H and C-C bond insertion reactions, in addition to the palladium-catalyzed aerobic oxidative kinetic resolution recently developed in these laboratories.
منابع مشابه
Ab initio Study of Simple Mg-Ene Reactions of Propenyl Magnesium Halides and Ethylene (Type-I Intermolecular Reaction)
The insertion of an olefinic C=C bond into a metal-carbon bond is of potential interest as a preparativeroute to new products and as results of C-C coupling reactions to organic compounds. The allyl compoundsof Mg, react with an olefin by inversion of the allyl group via a six center transition state. These precyclicreactions may be one of the most important classes of organic reactions. The re...
متن کاملPd-catalyzed enantioselective aerobic oxidation of secondary alcohols: applications to the total synthesis of alkaloids.
Enantioselective syntheses of the alkaloids (-)-aurantioclavine, (+)-amurensinine, (-)-lobeline, and (-)- and (+)-sedamine are described. The syntheses demonstrate the effectiveness of the Pd-catalyzed asymmetric oxidation of secondary alcohols in diverse contexts and the ability of this methodology to set the absolute configuration of multiple stereocenters in a single operation. The utility o...
متن کاملNano-Fe3O4 as a heterogeneous recyclable magnetically separable catalyst for synthesis of nitrogen fused imidazoheterocycles via double C-N bond formation
An efficient and convenient approach towards the synthesis of nitrogen fused imidazoheterocycles through double C-N bond formation in a single step has been achieved with a good range of substituted phenacyl bromides in the presence of magnetically recoverable Fe3O4 as a green heterogeneous nanocatalyst. The present approach was found to be environmentally benign and econo...
متن کاملNano-Fe3O4 as a heterogeneous recyclable magnetically separable catalyst for synthesis of nitrogen fused imidazoheterocycles via double C-N bond formation
An efficient and convenient approach towards the synthesis of nitrogen fused imidazoheterocycles through double C-N bond formation in a single step has been achieved with a good range of substituted phenacyl bromides in the presence of magnetically recoverable Fe3O4 as a green heterogeneous nanocatalyst. The present approach was found to be environmentally benign and econo...
متن کاملSYNTHESIS AND CHARACTERIZATION OFSILICON CARBIDE NANO POWDER BYSOLGELPROCESSING
Abstract: SiC nano particles with mono dispersed distribution were synthesized by using of silicon alkoxides and phenolic resin as starting materials. After synthesis of sample, characterizations of the obtained powder were investigated via Fourier Transform Infrared Spectroscopy (FTIR) with 400-4000 cm-1, X-ray Diffractometry (XRD), Laser Particle Size Analyzing (LPSA), Si29 NMR analysis, Scan...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of the American Chemical Society
دوره 128 36 شماره
صفحات -
تاریخ انتشار 2006